Mr. Mime first appeared in Valerie's gym with Spritzee, Sylveon, and Mawile. Mr. Mime looked a bit upset, since Valerie was concerned about the upcoming fashion show, but happily greeted Serena and Bonnie.
Valerie and her Pokémon, including Mr. Mime, watched Lysandre's broadcast from Lumiose City.
None of Mr. Mime's moves are known.