A Two-Edge Orb in the Pokémon Mystery Dungeon series is an item that will halve all the current HP of all Pokémon in the same room as the player (including the player's HP too) when used.
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| List of Pokémon Mystery Dungeon Orbs |
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| All-Hit - All-Mach - Blowback - Brushoff - Cleanse - Decoy - Drought - Escape |
| Evasion - Fill-In - Foe-Petrify - Foe-Seal - Foe-Stun - Hail - Hurl - Identify |
| Invisify - Itemizer - Lob - Longtoss - Luminous - Mobile Orb - Mug - One-Room |
| One-Shot - Petrify - Pierce - Pounce - Quick - Radar - Rainy - Rebound |
| Rocky - Rollcall - Sandy - Scanner - See-Trap - Shocker - Silence - Sizebust |
| Slow - Slumber - Snatch - Stairs - Stayaway - Sunny - Switcher - Totter |
| Transfer - Trapbust - Trapper - Trawl - Two-Edge - Warp |