|Japanese Name:||セレナ Serena|
|Hometown:|| Vaniville Town (current)|
Pallet Town (prior to start of series)
|First Appearance:||XY001: Kalos, Where Dreams and Adventures Begin!|
|Voice actor:|| Mayuki Makiguchi (Japanese)|
Haven Paschall (English)
Despite the fact that Serena is Ash's newest female companion and has just started her journey, she met him when they were younger back in Pallet Town years ago and have been together as childhood friends a long time before he started his journey. Her main color is pink.
Serena marks a return to basing Ash's female companion off of that generation's female player character. However, Serena is also the first to have undergone minor cosmetic changes for the transition to the anime, whereas May and Dawn remained the same. Among the cosmetic changes are:
- The hair is a much darker shade, and seems slightly shorter.
- Shirt collar is white instead of black.
- The sunglasses on the hat and the bracelet on her left wrist are absent.
- Her eyes are blue despite the fact that her hair is not blonde like her game counterpart, where they should be grey, matching her current hair color.
- The bow that's on her hat is not on her game counterpart.
- She wears shoes unlike her game counterpart, which wears sneakers, however they are in the same design.
- She also does not have her purse that her game counterpart does.
- Serena is Ash's first companion to have known him personally before the very start of the series.
- She is the second main character to keep her Japanese name. The first is Iris.
- Serena is the third of Ash's female companions to be based on the female player character in her debut generation, the first two being May and Dawn. However, Serena is the fourth female companion to have a charater equivalent in the games at all, as Misty exists in the games and was the first traveling companion of Ash's.
- Serena does not sport sunglasses like her game counterpart.
- Like Dawn, Serena is the second of the female traveling companions that isn't a Gym Leader, related to one, or to be one in the future. Misty is related to her three older sisters who were the former Gym Leaders of the Cerulean City Gym, until JE157: Gotta Catch Ya Later, when she had to become the Gym Leader when her sisters set out on a trip around the world. May is the daughter of Norman, who is the Gym Leader of the Petalburg City Gym. Iris was hinted, soon revealed to become the successor to Drayden of the Opelucid City Gym.
- Serena is also the third traveling female companion to sport head gear. May and Dawn were the first two.