|First Appearance:||XY001: Kalos, Where Dreams and Adventures Begin!|
|Voice actor:||Mayuki Makiguchi (Japanese)|
Despite the fact that Serena is Ash's newest female companion and has just started her journey, she met him when they were younger back in Pallet Town years ago and have been together as childhood friends a long time before he started his journey.
Serena marks a return to basing Ash's female companion off of that generation's female player character. However, Serena is also the first to have undergone minor cosmetic changes for the transition to the anime, whereas May and Dawn remained the same. Among the cosmetic changes are:
- The hair is a darker shade, and seems slightly shorter.
- Shirt collar is white instead of black.
- The sunglasses on the hat and the bracelet on her left wrist are absent.
- Her eyes are blue despite the fact that her hair is not blonde like her game counterpart, where they should be grey, matching her current hair color.
Currently unknown, though she is seen with a Fletchling.
Serena is Ash's first companion to have known him personally before the very start of the series.