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Serena may refer to:
- The optional player character in Pokémon X and Pokémon Y: Serena (game)
- The female protagonist in Pokémon The Series XY and a childhood friend of Ash Ketchum: Serena (anime)
- A minor character that appeared in AG092: Judgement Day!: Serena (Hoenn)
- A minor character who is also a reflection from the reflection cave in XY036: Mirror Serena