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Serena may refer to:
- Serena (game), a playable character in the X and Y games.
- Serena (anime), a main character in the Pokémon anime.
- Serena (Hoenn), a minor character that appeared in AG092: Judgment Day!.
- Mirror Serena, a minor character that appeared in XY037: The Cave of Mirrors!.
- Y or Yvonne Gābena is Serena's counterpart in the Adventures manga.