Saffron City is home to Sabrina, the Psychic-type Gym Leader.
In the games
Saffron City is present in the First, Second, and third(Remakes) Generations of Pokemon. In Pokemon Red and Blue (and Green) saffron is home to both a Offical pokemon leauge Gym (Sabrina) and an Un-Offical "Dojo"
Aperances in Anime/Manga
Ash goes to Saffron in the Anime in order to get the Marsh Badge,but was unable to beat Sabrina's Kadabra with Pikachu. He Contined his journey and later returned with a Haunter, however instead of battling Sabrina's pokemon it chose to Play around, causing the emotionless Psychic to burst into laughter. as a reward, Ash was presented with the Marsh Badge