In the Anime
The laboratory debuted in the first episode, Pokémon - I Choose You!, when Ash received his Pikachu. Since then, it has been seen in many episodes, mostly in the start and ending of a region adventure, but also in Pokémon Chronicles and in the movies. The building stands out in Pallet Town because of its wind turbine, the three windows of the inner balcony, and the four windows of the second floor. Every time Ash captures a Pokémon when he has six already with him, the new Pokémon is automatically transported here. Ash also has a habit of leaving all of his Pokémon besides Pikachu here each time he leaves for a new region, starting with Hoenn.
In the Games
In the games, the lab is where Professor Oak can be found if the player needs speak to him for help or advice. He studies Pokémon all day in his lab, assisted by aides. There are many different machines in the lab that are used by Oak for his research. One of the machines is a Pokédex, which Professor Oak gives to the player along with five Poké Ballss after they are given a starter Pokémon. The Pokémon are kept on a table in the top-right corner and the player is allowed to choose any of them. Once the player defeats the Elite Four in Pokémon FireRed or LeafGreen, Professor Oak will update the player's Pokédex to the National Dex.