Misty accompanied Red to Mt. Moon. Red thought she was not tough to take on Team Rocket, but Misty showed the Pokémon she had, including Starmie, to prove she was capable to fight. After leading Red to her Gym, Misty introduced herself as the Gym Leader of Cerulean City. Red thought she was joking, so Misty sent Starmie to soak him. Red, who was told Misty was the one that had her Gyarados attack him the night before, sent Bulbasaur to retaliate with Vine Whip. Misty simply repelled the attack with her Starmie's Bubble Beam. Red heard how Misty was concerned they could be defeated the next time by Team Rocket, and decided to train with her.
Since Red nearly drowned near Seafoam Islands while battling a Dragonite, Misty had Starmie save Red. Misty, Staryu and Starmie joined in the attack against Team Rocket at Saffron City, and secured the northern gates.
Misty had Staryu and Starmie defend Cerulean City from armies of Haunter and Gengar. To signalize to the trainers on Cerise Island that Kanto's cities were attacked, Misty had Starmie go to the sky to illuminate the message. A Haunter went to throw a rock at Starmie, so Misty had Krabby shatter the rock with Guillotine. Starmie illuminated the message, while Misty hoped the people at Cerise Island saw that message.
While passing through the Tohjo Falls, Misty fell from Brock's Onix. She had her Starmie save her, and, upon seeing Krabby, she went to rescue it. Misty fainted, but Starmie carried her inside the cave, where Misty woke up. Upon encountering Suicune, Misty had her Starmie battle it, but Starmie was quickly overwhelmed. Once Misty fell into the stream, Suicune began speaking to her by having Starmie write a message in ancient star language by using psychic waves.
Starmie fought against Whitney's Miltank; Miltank used Rollout, but was countered by Starmie's Rapid Spin, followed by Flash. With Hyper Beam, Starmie defeated Miltank, knocking Whitney out of the tournament.
|Bubble Beam||Suddenly Starmie|
|Rapid Spin +||Notorious Noctowl|
|Hyper Beam||Notorious Noctowl|
|+ indicates this Pokémon used this move recently.*|
- indicates this Pokémon normally can't use this move.
- ^ RGB006: Gyarados Splashes In!
- ^ RGB008: Suddenly Starmie
- ^ RGB024: What a Dragonite
- ^ RGB033: The Winged Legends
- ^ YL008: Paras Sight
- ^ YL015: The Primeape Directive
- ^ YL025: Karate Machop
- ^ YL037: Striking Golduck
- ^ YL039: Airing Out Aerodactyl
- ^ CR034: Chinchou in Charge
- ^ CR035: Lovely Lanturn
- ^ CR038: Yikes, It's Yanma!
- ^ CR040: Notorious Noctowl
- ^ CR049: Lugia and Ho-Oh on the Loose (Part 1)
- ^ CR052: The Last Battle II