Lisa challenged Ash to a battle at the beginning of The Spell of the Unown. She started with her Granbull against Ash's Totodile. It tried to used Bite on it, but Totodile's happy dancing helps him avoid the attack. Totodile defeated Granbull with his Water Gun.
After the battle, while all the Pokemon were having lunch, Granbull was seen with Totodile, who were both roaring at each other for unknown reasons.