Jessie's Wobbuffet is one of Jessie's main Pokémon, but she doesn't use him in battle much. Like Misty's Psyduck, he likes to pop out of his Poké Ball randomly. Jessie got it by accidentally trading her Lickitung for him. It knows the move Counter, but it fails to perform it on many occasions. When Jessie, James and Meowth are blasting off, Wobbuffet and Mime Jr. finish by saying "Wobbuffet!" and "Miiiiiime mime mime!" Wobbuffet acts as a comic relief. Jessie left her Wobbuffet at Team Rocket HQ along with her Yanmega and Seviper when they went to the Unovaregion.
It is set to reappear in a Pikachu short that will come out in the 15th Pokémon movie. Also, He is the third most seen Pokémon in the anime, Behind Meowth and Pikachu.