While en Route to Ecruteak City, Ash and co. find a Pidgey being pursued by a Fearow and help it. Ash brings out his Noctowl to help and help it did: it drove the Fearow away and calmed the Pidgey. Later they meet the Pidgey's trainer, a young boy named Malachi and his grandfather, who started a delivery service known as "The Pidgey Express". Team Rocket also has plans for the Pidgey, but what could they be, and why is the Pidgey with the hat named "Ken"?
Mewtwo (the Pokémon in this episodes "Who's that Pokémon segment) says "Prepare To Battle", probably as an homage to the Mewtwo in Pokémon: The First Movie.