Greta's first (and only) appearance in the Anime series was in the episode Wheel... of Frontier!. During this episode, Ash challenged Greta to a battle for the Guts Symbol. Before the two began though, a wheel was spun to see how many Pokémon could be kept for the battle. The Battle ended when Ash's Snorlax defeated Greta's Medicham, therefore Ash gained the Symbol.
When Greta was not battling Ash, she was seen running her own karate dojo. Sometime during the episode, Scott stated that before she was a Frontier Brain, Greta trained with two Gym Leaders: Brawly from Hoenn, and Chuck from Johto.
Greta first appeared in Pokémon Emerald, as the Frontier Brain for the Battle Arena. She appears after 27 consecutive wins for the Silver Guts Symbol, and again after 55 wins for the Gold Guts Symbol. Upon meeting the player she questions their strength as a Trainer, but with her defeat Greta seems almost excited by the fact that someone beat her.
In the anime, Greta and Ash are barefoot during their entire battle, along with Brock, May, Max, and Scott, and Jesse and James as well. Greta is so strict on martial arts, she makes everyone remove their shoes and socks before entering. Ironically, her casual sneakers detract from the appearance of a full-fledged martial artist, unlike when she's in her bare feet.
Greta was the second Frontier Brain that Ash defeated.