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Cofagrigus was sent out with Ghetsis' other Pokémon to attack Black's Pokémon, after he defeated N and Zekrom with Reshiram. It grabbed hold of Musha during the flames, but Costa managed to free it once Eelektross, who was using Thunderbolt on it, was defeated by Brav. It was defeated, along with all of Ghetsis' Pokémon, by Black's Pokémon attacking at once, with Brav using Sky Drop against it.
None of Cofagrigus' moves are known.