With the Sinnoh League behind them, Ash and friends take a ship back to Dawn’s hometown of Twinleaf. A crisis emerges, however, when a group of Tentacruel attack the ship and poison many of the Pokémon on board. With no other doctor on the ship, Brock is the only one who can help those Pokémon. Will he succeed before it’s too late?
There is no Professor Oak's Pokémon Lecture at the end of this episode. Instead, a preview of the Best Wishes series featuring Snivy, Tepig, and Oshawott was shown.
Oración, Together With the Wind, and music from Route 29 are used as the background music in this episode.
Ash, Brock, and Dawn narrate the preview of the next episode.
While they are looking for treasure, Team Rocket make a reference to several games. They wonder if the treasure will be Gold, Silver, Ruby, Sapphire, Diamond, Pearl, or Platinum. James also makes a reference to the upcoming games by saying, "It's not quite that Black and White" in the dub.
Despite the fact it has existed since Generation I and is known as Chansey's signature move (plus the fact that Chansey have made regular appearances in the anime since the second episode), this episode marks the first time that Softboiled is used in the anime.
The dub's title is based on the phrase the doctor is in.
This episode shares some similarities with Pinch Healing!. They have a similar plot of Brock taking care of sick Pokémon that belong to a daycare worker in the absence of Nurse Joy and it is near the end of the series.
This is the final episode where Michele Knotz voices Nurse Joy.
Team Rocket doesn't recite the motto in this episode.
This is the first time when the move Splash has been used in the anime by other species of Pokémon than Magikarp that doesn't use it as a result of Metronome.
This is the second time in a row when a main character's Pokémon evolves in the second to last episode of an anime series.
In the Hindi dub, Happiny is referred to as a male multiple times in this episode, even though it is a female-only species.
In the Portuguese dub, Brock says that Jigglypuff's fever was gone, but it was actually an Igglybuff.
Normajean's Teddiursa is seen using Pound despite not being able to legally learn the move in the games.
Despite Wynaut's Ruby Version Pokédex entry claiming that it is impossible for it not to smile, Wynaut was seen not smiling at several points during this episode.
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