Cheryl made her debut in Some Enchanted Sweetning where she was looking for the Amber Castle.
Cheryl first sent out her Chansey when she had seen a Burmy had gone to eat some of the Sweet Honey she had planted. After using Attract to determine Burmy's gender, she then had Chansey battle it. After wearing it down, she captured Burmy. Cheryl also sent out Chansey to battle against Team Rocket when they stole her Burmy.
Chansey's known moves are Attract, DoubleSlap, and Egg Bomb.
Mothim was first seen as a wild Burmy in the Eterna Forest. Cheryl has spread some Honey on a tree in hopes of attracting a Burmy. After confirming Burmy's gender to be male, she proceeded to capture it. She explained to Ash and his friends that she needed a male Burmy to evolve into a Mothim in order to find the Amber Castle. Cheryl then trained Burmy in order to evolve and it finally did during a battle with Team Rocket.