The gang walks down a path, while Pikachu seems exceptionally happy. Suddenly, a tree falls down! As the smoke clears, Team Rocket captures Pikachu using a robot. Pikachu uses Thunderbolt, but with no effect, as the robot is made of a material that does not conduct electricity. The gang goes to get him, but fall in a hole. Soon, the robot falls as well, due to the material it is made of. The robot explodes and everyone blasts off, splitting Ash and Pikachu. The gang wakes up and Ash goes after Pikachu, but everyone is stuck on the tree. James, Wobbuffet and Jessie are bashed on a tree. They go off from it, so James suggests to search for Meowth, but Jessie thinks they should return to the base. However, they become lost.
Pikachu and Meowth are seen together. Meowth yells for Jessie and James to come to him, but sees nobody is around. Meowth has no choice but to battle him - he goes to scratch him, but Pikachu does nothing. Pikachu tells him that he has no idea where he is or who is his trainer. Meowth realizes that Pikachu lost his memory, so plans to fill his head with new info to banish the old memories. Meowth tells Pikachu that he had been a member of Team Rocket from the day he was born. Ash tells Swellow to search for Pikachu and Brock tells Mudkip the same. Afterwards, Pikachu and Meowth walk down a path. A Zigzagoon appears, hiding behind Pikachu - a Beedrill appears as well, trying to attack. Pikachu uses Thunderbolt, making it leave.
Meowth thinks Pikachu is a kind creature, so plans to take advantage of it, so they leave. James and Jessie are seen to search for Meowth and "the home base" (even if James tells her the home base is far from here). Meowth and Pikachu walk through the edge of a mountain. Meowth begins to be bluffing, but shakes it head. He tells him he saved his life once. Suddenly, Meowth almost falls, but Pikachu grabs him on his tail and pulls him back. The gang searches more. Mudkip feels something and they all see footprints of Pikachu, Meowth and Zigzagoon. Meowth begins to feel hungry, so Pikachu gives him an apple. Meowth hears that Pikachu gave him the only apple he saw, so Meowth begins to cry. He splits the apple in half, giving the larger to Pikachu.
The gang sees more footprints of Pikachu and Meowth, though they are concerned that Pikachu did not battle, from the looks of the tracks. Swellow searches the area while Meowth and Pikachu follow a path. Pikachu rolls back, but Meowth stops him, so they continue the path. Team Rocket see a base and go inside to rest. Swellow spots them entering the building and goes back. Meowth and Pikachu arrived to the base as well. James is thrilled to see Meowth back, but he and Jessie see Pikachu wanting to battle them. Meowth says that he is their friend now and whispers what really happened. Mudkip searches and his fin turns to a side. Swellow appears to let Ash know what it found. Jessie and James persuade Pikachu that they are also his friends, succeeding in fooling him.
Pikachu goes on James' shoulder (even if Pikachu is heavy). They play for a while, then the gang appears. Meowth and Ash try to convince Pikachu what they want, but Pikachu is confused. When Meowth says he is a liar, Pikachu goes to Team Rocket. Ash realizes Pikachu does not remember him and tries to convince him that he does not belong to Team Rocket, but with a faliure. James orders Pikachu to use Thunderbolt, attacking Ash. Mewoth orders to do so again, attacking Ash once more. Brock realizes Pikachu hit his head and has an amnesia problem. Team Rocket depart in the balloon. Ash goes on the balloon and Pikachu uses Thunderbolt, but electrocutes everyone. Team Rocket is blasted off while Pikachu and Ash fall down.
Ash catches Piakchu and falls in the river. A flashback of Ash and Piakchu's adventures in Hoenn is shown and they go down the river. Next, Ash is seen on the river shore and Pikachu licks him to wake him up. Pikachu remembers Ash in his memories. Brock, Max and May arrive and see Ash reunited with his best friend. Team Rocket has blasted off near the river and the gang says they should help themselves get out of the river. Team Rocket attempts to convince Pikachu to get back, but soon learn that he got his memory back when Thunderbolt is used on them. At the rest of the day, Ash promises that he will never lose Pikachu again and everyone goes to Lilycove City.
- The dub features a song written especially for this episode, titled You Can't Remember.
- This marks the first and so far only instance of Team Rocket reciting their motto more than once in an episode without any interruption.
- Meowth returns the favour to Pikachu by splitting the apple between them, as Pikachu did the same to Meowth in an earlier episode.
- The dub title is a reference to the film A Walk to Remember.
- In the Japanese version, when Ash and Pikachu are floating through the river, Ash has flashbacks of his Gym battles with Roxanne and Norman. These are both cut in the dub.